Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition

Humane endpoints for infectious disease animal models.

Since the work of pioneers such as Jenner and Pasteur (Fenner et al. 1997) more than a century ago, animal models have provided essential information in the study of infectious diseases. Although much experimentation can now be accomplished with in vitro systems, animals continue to be necessary for this field for studying the process of inflammation, specific infectious diseases, and pharmacol...

Pain management and humane endpoints.

Studying humane endpoints in a rat model of mammary carcinogenesis

Objective(s): The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/...

Endpoint matrix: a conceptual tool to promote consideration of the multiple dimensions of humane endpoints.

This paper proposes a framework to support appropriate application of endpoints in animal experiments. It is recommended that unpredicted endpoints should be explicitly considered alongside scientific endpoints and justifiable endpoints as the three types of endpoint which comprise the "humane." We suggest there is a need for clear identification of each type of endpoint and an understanding of...

Thermal conductivity of Water-based nanofluids: Prediction and comparison of models using machine learning

Statistical methods, and especially machine learning, have been increasingly used in nanofluid modeling. This paper presents some of the interesting and applicable methods for thermal conductivity prediction and compares them with each other according to results and errors that are defined. The thermal conductivity of nanofluids increases with the volume fraction and temperature. Machine learni...